Start at Žužemberk taking the road 216 to Dvor. Drive thru Dvor and at Soteska drive straight to 419 in direction of Novo mesto.
In Novo mesto just keep on 419 straight thru the city (direction Šentjernej). After Šentjernej you shall arrive at Kostanjevica na Krki. Small village on an island made by two channels of Krka river.